There are different types of osteomyelitis. Just like in case with many other diseases, it is difficult to categorize it into one class. The most common signs of this health issue involve painful sensation inside the bone and in the areas around, which varies from mild to advanced level. The patients also may notice tumors under the skin where the infected bone is located.The damaged parts of the body may get pinky, reddish, or purple. The skin around the infected region becomes very sensitive and tender, so the patient should be really careful with other possible traumas. Swelling and annoyance are two other symptoms of osteomyelitis. People with such diagnosis get quickly tired and remain exhausted even after having a good sleep. So, fatigue is another warning sign.