Once it achieves the main target, bloodstream, the infection becomes rather dangerous and even life threatening. It may also expand from the tissue close to the bloodstream. The problem takes place inside the damaged bone. A disease processes the injured bone to microorganisms. Lower extremities and upper areas of top extremities are usually infected, especially when talking about little patients. As for the grown-up population, osteomyelitis will most likely occur in the spine (a.k.a. vertebrae).