Throbbing ache in the lower-right abdomen. In the initial stages of appendicitis, the pain is general and centered around the navel. However, as the condition progresses, and especially if it is untreated, the pain tends to localize and focus upon the appendix itself, that is to say, in the lower-right abdomen. The pain is agonizing and has been likened by some sufferers to being shot in the stomach, or the experience of birthing a child. This pain, unlike the general pain at the onset of the condition, is a decisive indicator of appendicitis and is used by physicians to diagnosis.