Disinterest in eating. One of the first manifestations of appendicitis is a disinclination to eat. The abdomen will feel tender and with the onset of the initial pain, the patient will begin to avoid food. This is not a decisive indicator of the condition, but, when taken with other indicators of the same, can be considered a definite symptom of the ailment. It is a factor adding to the manifest danger of this condition – to the dangers of infection are added a lack of intake of food and drink, which can rapidly lead to dehydration, as well as to general weakness.