There are certain threatening factors one should keep in mind. Under the risk factors, the doctors usually mean those that may provoke the illness. The variola virus is exterminated by today. However, there are still certain risks for people working in the lab and conducting experiments associated with the usage of this virus.Bio weapons attack also may give life to the variola virus. Earlier, the threats included all infected people, dangerous fluids or droplets in the air carrying the virus from person to person. The patients with smallpox coughed, so the chances were really high.