The signs depend on the type of this disease. Their complexity also depends on the external/internal involvement of the patient. One of the organs is attacked most of all: blood vessels, kidneys, bowels, or lungs. This disease has an impact on the body’s surface in the shape of ongoing inflammation and irritation. A patient can notice his skin turning too sensitive, itchy, and painful. Besides, it turns red. In the end, a skin may harden. Most of the time, human limbs and face suffering. It leads to the drop in movement.