It is impossible to name the main cause of Scleroderma accurately. Thanks to the numerous studies, it is possible to say that certain genes may take part in passing the predisposition to this disease. Another important factor to consider is the environment. In the end, the immune system activates. It harms the internal lining of the small blood vessels. Such activation also does damage to the tissues. A consequence is the appearance of a scar tissue as well as the storage of collagen, which is abnormal and not good at all.