Getting overwhelmed and exhausted even when doing simplest daily activities is always a sign of the bad health condition, but it is especially important to notice in case of leukemia. Red blood cells should bring oxygen to every part of the organism to let it functions properly. A number of red blood cells may suddenly drop. If it happens, there is no proper element responsible for delivering oxygen to the entire body. Anemia and long-lasting fatigue are the results of leukemia symptoms.