As far as the nature of erythema nodosum is rather harmful to skin’s appearance, patients do everything possible to fully recover and look fine again. It is critical to identify the underlying problem unless the disease is chronic. Determine the character of the skin lesions or leave it to a doctor. He will then prescribe the necessary medicine. Two most popular approaches to curing erythema nodosum include: anti-inflammatory drugs, cortisone (taken by mouth or via injection).