Issues with breathing. Research studies done in the United Kingdom found that between half to nearly three quarters of all those who suffer from throat cancer will have serious issues with their breathing. If the sound that you make while breathing changes to a considerable extent from your norm, and especially if it is high pitched or extremely loud, it could be a symptom of a serious condition. Problems in breathing and noisy breathing occur when a cancer of the larynx constricts the voice box, or else the vocal cords themselves.