Chest pain. Chest pain is the most usual and obvious symptom of mesothelioma. As like infiltration of the pleural lining mesothelioma is very painful and will lead you to the hospital right away. The pain you feel is very sharp and goes right into your chest, so you will not miss it. To be more accurate, the pain is usually located at the place of your lungs where the cancer is developing. But sometimes it can be formed in other parts of your lungs. Also, some people often mistake such pain as a muscle strain and wait when it is over.