A soreness in the throat. This isn’t the simple soreness that one associate with the common cold – that caused by infectious mononucleosis is extremely intense. Ingesting anything can become difficult, or all-but-impossible, including the swallowing of one’s own spittle. The defining factor that sets soreness of the throat that is caused by mononucleosis apart from that caused by a cold, is that the other common symptoms of a cold will be absent. You will not sneeze, or have a cough, or experience a running nose.