The moles a person already has might be changing in shape and size. Even the birthmark can be affected, so one should pay attention. The most affected regions are the patient’s back or extremities, especially lower limbs. Women suffer from these symptoms even more than men. Fingers and toenail beds may get hurt as well. Some people report having problematic skin in the areas like face and neck; some people experience these troubles in mouth, rectum, or vagina.