Lethargy and overall tiredness. Lyme disease has an exhausting effect upon the body, equally prevalent in both minors and adults. This disease can massively deplete energy reserves as the body tries to fight it off. Many people find themselves turning in early at night, and finding it exceedingly hard to wake up in the morning. Patients will also feel extremely drowsy during the day and may nap uncontrollably. Often, the drowsiness is so pronounced and the energy levels so low that there is no option but to sleep for a while.