Symptoms reminiscent of the flu. This is one of the most obscure indications of Lyme disease. Virtually all viral attacks cause symptoms similar to the flu, and Lyme disease is no exception. Patients will experience pains in the head and body, a fever, and a running nose, as well as lethargy and a loss of energy. However, unlike the flu, Lyme disease is treatable, and with treatment, these symptoms will disappear within a week.