A person will experience chills, high fever, and ache in the chest. A dry cough supports all of these. Add sweating as the outcome of relatively high fever and body temperatures. Malaise is one more thing, which could help to determine the health condition. In rare cases, the joint ache is also present. In serious situations, people diagnosed with histoplasmosis may lose their weight rapidly, run out of breathing, and feel extra tired all day long.