What does examination involve? In order to diagnose histoplasmosis accurately, several tests are necessary to consider. First of all, in some cases, the person will have no idea of being infected as sometimes no symptoms show up, and the disease is gone on its own. Only patients with the severe consequences and signs as well as people living in the areas with high risk should regularly check for histoplasmosis. To verify this health condition, the healthcare professional may ask you to pass two basic types of tests: urine and blood exams.