The following threats may increase the alveolar-capillary permeability, the source of the problem: irregular capillary hydrostatic pressure (higher than normal); bacteraemia (the presence of bacteria in the human blood); overdose of inspired oxygen; endotoxemia (when endotoxins are in blood); attack of volatile hydrocarbons; smoking (as this bad habit impacts lungs adversely); cocaine (or similar drugs) inhalation; adverse reaction to metal dusts; upper respiratory infections; genetics; therapies like alemtuzumab.
The last factor is extremely important, as it was discovered not so long ago. Goodpasture’s syndrome possesses higher risks for people who possess so-called human leukocyte antigen (HLA). Moreover, even when diagnosed on time, they still find it more complicated and time-consuming to fully recover.
If the person notices higher exhaustion level, breathlessness, pale skin, and desire to vomit without some good reasons, those are warning signs in any case. Unfortunately, Goodpasture’s syndrome has this dangerous signs among its main symptoms as well. Because the lungs and kidneys suffer more than other organs, it is reflected in the lack of breath. Patients find it hard to breathe deeply, so they may even wake up at night, feeling they are simply running out of the air. Then, they start coughing hardly, often releasing blood with the saliva.