Liver dysfunction and Jaundice. In more serious attacks of gallbladder disease the bile duct can actually become infected or blocked, and inevitably, an excess of bile builds in the liver. Waste products (bilirubin) begin to accumulate in the blood, causing the classic symptoms of jaundice. Thus, jaundice, while it can be indicative of a wide range of health conditions, is also an indicator of severe gallbladder disease. The skin acquires a yellowish tinge, as does the white area in each eye.