Running a temperature and shivering. Fevers are usually linked to infections. People suffering from gallbladder attacks do not usually experience fevers. However, if the other symptoms of a gallbladder attack are prevalent, and the patient is suffering a fever, it is indicative of the seriousness of the condition. Fevers usually occur when a gallbladder attack escalates into an infection (cholecystitis). At this point, the patient will not only be running a temperature but will also be vomiting at intervals. This is a serious condition that could well prove fatal, as gangrene may set in, or the wall of the gallbladder itself might be breached.

Symptomatic and visible changes in urine. One of the most powerful indications of gallbladder disease is passing urine of an indicatively dark color. Such urine can range in color from a deep brown to a deep brown with a yellowish tinge. This dark tinting is actually bile pigmentation induced into the urinary tract by the disease. This is an extremely clear indicator that the disease is present, and is a fairly early warning that something is wrong, and if treatment is sought at this point, many more serious consequences of the disease may be avoided. Discolored urine can also be indicative of conditions arising from the bladder and even the kidneys.

Liver dysfunction and Jaundice. In more serious attacks of gallbladder disease the bile duct can actually become infected or blocked, and inevitably, an excess of bile builds in the liver. Waste products (bilirubin) begin to accumulate in the blood, causing the classic symptoms of jaundice. Thus, jaundice, while it can be indicative of a wide range of health conditions, is also an indicator of severe gallbladder disease. The skin acquires a yellowish tinge, as does the white area in each eye.

Irregularities in color and texture of stools. Gallbladder disease causes blockage of the bile ducts, causing unusually large amounts of fats to get eliminated within the stool, causing a noticeable alteration of not just the color, but also the consistency of the stool, making it come across more yellow and clayish rather than brown and solid. If left unattended, this disease could eventually lead to very loose stools, which at times can result in volatile movements of the bowel accompanied by a rotten smell, symptomatic of a gallbladder attack.