In most cases, the facial muscles are attacked more than other muscles. In fact, the patient’s head and neck feel discomfort more than the extremities. One of the first signs to show up is the rejection to keep the mouth closed. The person simply cannot control his facial expressions as the responsible muscles are unable to function correctly. Any attempts to cry, sing, or smile also result in a failure when Myasthenia Gravis is at its peak. The person seems rather tired or deeply sad.