Permanent tiredness and petulance. If we assume that a patient experiences a number of the symptoms, actually, this patient must have cholera, just for example. Try to remember the list of cholera symptoms – permanent thirst, dehydration, bad smell, vomiting, weight loss, etc. It is more than logical that the mood is awful in this case. Sickness irritates to such an extent that it drives the patient mad. Thus, the symptoms mentioned influence negatively on mentality and on the nervous system, not on the body only.