Local areas of the body feel numb. Since neuropathy directly degrades the function of the nerves, especially those connected to the senses, it makes sense that you should lose sensation in certain local areas. As the condition progresses, the nerves are more and more incapable of transmitting information connected to sensory perception. The individual will lose the ability to experience touch, or feel pain, or sense temperature. The lower limbs are the most affected by this sensory degradation.

Raised levels of blood sugar. Raised levels of blood sugar are closely related to peripheral neuropathy, as diabetes is often a contributing factor to this condition. Consistently high levels of blood sugar tend to damage nerves in the extremities of the body, that is to say, the peripheral nerves. Over time, nerve endings can actually be destroyed, and a proportional amount of sensation is lost.

Unexplained local pains. As the nerves in the peripheral regions of the body are damaged, they start sending incorrect stimuli to the brain. This can result in the patient feeling random, unexplained pains in the lower extremities of the body. Also, quite normal stimuli, such as a gentle touch, can also result in pain. These abnormal sensations directly reflect the damage that is affecting the peripheral nerves.