Breathing difficulties. This symptom is also very wide spread in medical practice and can be mistaken with lots of other illnesses. Usually, people do not associate it with mesothelioma, but you should be aware of such danger. Of course, your breath shortens while you grow older and those people who have asthma also have breathing difficulties. But mesothelioma is no joke, and you should ask for help as soon as you discover any unusual difficulties.