Burning sensation, irritation, and inflammation. Tingling is not the only problem so far: people who suffer from this disorder complain of the burning hands. No matter whether the patient decides to take a nap at night or day time, the burning sensation may be an obstacle. If the hand remains without any movement for some time, it may be burning too. Most of the time, the area around thumb and other fingers hurts. It happens because of the pressure on the median nerve.